Magnetic Therapy and Neuropathy: a research
bibliography.
Pulsed magnetic field therapies have been found to have
beneficial and protective neurological effects. Beside
promoting various physiological, psychological and neurological
healing mechanisms, PEMF's turn on body's ability to regenerate
bone, muscle and nerve tissue. See also our bibliography on
Magnetic Therapy and
Pain with many more studies on pain than simply those
termed neuropathy / neuropathic.
Frequency Specific Pulsed
Electromagnetic Field (PEMF) Research Bibliographies:
Several
hundred pulsed electromagnetic field therapy citations contained
in our research bibliographies are linked directly to PubMed
a service of the U.S. National Library of Medicine and the U.S.
National Institutes of Health. These studies are offered for your education only and are not intended as promotional material.
See also; Sandyk R, Anninos PA
, Jacobson
JI; three pioneers of electromagnetic field therapy to
treat Parkinson's, Alzheimer's and epilepsy.
PEMF Background:
PEMF Research By
Effect:
EarthPulse research:
one 20 minute application of 10 Hz rTMS study
->> Neurophysiol Clin. 2001 Aug;31(4):247-52.
Interventional
neurophysiology for pain control: duration of pain relief
following repetitive transcranial magnetic stimulation of the
motor cortex.
Lefaucheur JP, Drouot X, Nguyen JP.
Source
Service de physiologie-explorations fonctionnelles,
hôpital Henri-Mondor, Inserm U421, faculté de
médecine, 94010 Créteil, France.
another 10 Hz rTMS study->>> Pain Med. 2009
Jul-Aug;10(5):840-9. Epub 2009 Jul 6.
A pilot
study investigating the effects of fast left prefrontal rTMS
on chronic neuropathic pain.
Borckardt JJ, Smith AR, Reeves ST, Madan A, Shelley N, Branham
R, Nahas Z, George MS.
Source
Department of Psychiatry, Medical University of South Carolina,
Charleston, South Carolina 29425, USA.
Int J Diabetes Dev Ctries. 2009 Apr;29(2):56-61. in this study
hundreds of hertz worked; but not healthy for your neuro system!
Evaluation of
the efficacy of pulsed electromagnetic field in the management
of patients with diabetic polyneuropathy.
Graak V, Chaudhary S, Bal BS, Sandhu JS.
Source
Department of Sports Medicine and Physiotherapy, Guru Nanak Dev
University, Amritsar, Punjab, India.
Neurorehabil Neural Repair. 2004 Mar;18(1):42-6.
Pulsed
magnetic field therapy in refractory neuropathic pain
secondary to peripheral neuropathy.
Weintraub MI, Cole SP.
New York Medical College, Briarcliff Manor, New York
10510, USA.
CONTEXT: Neuropathic pain (NP) from peripheral neuropathy
(PN) arises from ectopic firing of unmyelinated C-fibers
with accumulation of sodium and calcium channels. Because
pulsed electromagnetic fields (PEMF) safely induce
extremely low frequency (ELF) quasirectangular currents
that can depolarize, repolarize, and hyperpolarize
neurons, it was hypothesized that directing this energy
into the sole of one foot could potentially modulate
neuropathic pain. OBJECTIVE: To determine if 9 consecutive
1-h treatments in physician's office (excluding weekends)
of a pulsed signal therapy can reduce NP scores in
refractory feet with PN. DESIGN/SETTING/PATIENTS: 24
consecutive patients with refractory and symptomatic PN
from diabetes, chronic inflammatory demyelinating
polyneuropathy (CIDP), pernicious anemia, mercury
poisoning, paraneoplastic syndrome, tarsal tunnel, and
idiopathic sensory neuropathy were enrolled in this
nonplacebo pilot study. The most symptomatic foot received
therapy. Primary endpoints were comparison of VAS scores
at the end of 9 days and the end of 30 days follow-up
compared to baseline pain scores. Additionally, Patients'
Global Impression of Change (PGIC) questionnaire was
tabulated describing response to treatment. Subgroup
analysis of nerve conduction scores, quantified sensory
testing (QST), and serial examination changes were also
tabulated. Subgroup classification of pain (Serlin) was
utilized to determine if there were disproportionate
responses. INTERVENTION: Noninvasive pulsed signal therapy
generates a unidirectional quasirectangular waveform with
strength about 20 gauss and a frequency about 30 Hz into
the soles of the feet for 9 consecutive 1-h treatments
(excluding weekends). The most symptomatic foot of each
patient was treated. RESULTS: All 24 feet completed 9 days
of treatment. 15/24 completed follow-up (62%) with mean
pain scores decreasing 21% from baseline to end of
treatment (P=0.19) but with 49% reduction of pain scores
from baseline to end of follow-up (P<0.01). Of this
group, self-reported PGIC was improved 67% (n=10) and no
change was 33% (n=5). An intent-to-treat analysis based on
all 24 feet demonstrated a 19% reduction in pain scores
from baseline to end of treatment (P=0.10) and a 37%
decrease from baseline to end of follow-up (P<0.01).
Subgroup analysis revealed 5 patients with mild pain with
nonsignificant reduction at end of follow-up. Of the 19
feet with moderate to severe pain, there was a 28%
reduction from baseline to end of treatment (P<0.05)
and a 39% decrease from baseline to end of follow-up
(P<0.01). Benefit was better in those patients with
axonal changes and advanced CPT baseline scores. The
clinical examination did not change. There were no adverse
events or safety issues. CONCLUSIONS: These pilot data demonstrate that
directing PEMF to refractory feet can provide unexpected
shortterm analgesic effects in more than 50% of
individuals. The role of placebo is not known and
was not tested. The precise mechanism is unclear yet
suggests that severe and advanced cases are more
magnetically sensitive. Future studies are needed with
randomized placebo-controlled design and longer treatment
periods.
Neurosci Behav Physiol. 2003
Oct;33(8):745-52.
The use of pulsed electromagnetic fields in
treatment of patients with diabetic polyneuropathy.
Musaev AV, Guseinova SG, Imamverdieva SS.
Science Research Institute of Medical Rehabilitation,
Baku, Azerbaidzhan.
Clinical and electroneuromyographic studies were performed
in 121 patients with diabetic polyneuropathy (DPN) before
and after courses of treatment with pulsed electromagnetic
fields with complex modulation (PEMF-CM) at different
frequencies (100 and 10 Hz). Testing of patients using the
TSS and NIS LL scales demonstrated a correlation between
the severity and frequency of the main subjective and
objective effects of disease and the stage of DPN. The
severity of changes in the segmental-peripheral neuromotor
apparatus--decreases in muscle bioelectrical activity, the
impulse conduction rate along efferent fibers of
peripheral nerves, and the amplitude of the maximum M
response--depended on the stage of DPN and the duration of
diabetes mellitus. The earliest and most significant
electroneuromyographic signs of DPN were found to be
decreases in the amplitude of the H reflex and the
Hmax/Mmax ratio in the muscles of the lower leg. Application of PEMF-CM
facilitated regression of the main clinical symptoms of
DPN, improved the conductive function of peripheral
nerves, improved the state of la afferents, and improved
the reflex excitability of functionally diverse
motoneurons in the spinal cord. PEMF-CM at 10 Hz was
found to have therapeutic efficacy, especially in the
initial stages of DPN and in patients with diabetes
mellitus for up to 10 years.
Fiziol Zh. 2003;49(2):85-90.
[Use of low-power electromagnetic therapy in
diabetic polyneuropathy]
[Article in Ukrainian]
Chebotar'ova LL, Chebotar'ov HIe.
The clinical-electroneuromyography investigations were
performed for objective evaluation of low-power
electromagnetic therapy effectiveness in 12 patients with
diabetic polyneuropaties. It is established that
combination of low-power electromagnetic therapy using
"ANET-UHF", "ANET-SHF" apparatus (Ukraine) and low-power variable
magnetic field using AMT apparatus (Ukraine) give
the stable positive effects. The positive changes were confirmed by
following: the decrease of neurological deficit and
required insulin daily dose, nerve conduction velocity
increase, increase of the muscle compound action
potentials (muscle power) and peripheral outflow in some
patients.
Zh Nevrol Psikhiatr Im S S Korsakova.
2002;102(12):17-24.
Application of impulse complex modulated
electromagnetic fields in management of patients with
diabetic polyneuropathy
Musaev AV, Guseinova SG, Imamverdieva SS.
[Article in Russian]
One hundred and twenty-one patients with diabetic
polyneuropathy (DP) underwent a clinical and
electroneuromyographic investigation before and after
treatment with impulse complex modulated electromagnetic
fields (ICM EMF) of varying frequency (100 and 10 Hz).
Based on TSS and NIS LL scale tests, a correlation between
the progression and occurrence of the basic subjective and
objective signs of the disease and a DP stage was
revealed. The alterations of segmental and peripheral
neuromotor system manifesting in reduction of muscular
bioelectrical activity, impulse conduction velocities in
efferent fibers of peripheral nerves and maximal
M-response amplitude were found to be related to DP stage
and diabetes mellitus duration. A decrease of H-reflex
amplitude and Hmax/Mmax ratio measured in crural muscles
proved to be the earliest and most significant
electroneuromyographic DP trait. ICM EMF application promotes a
regression of DP basic clinical symptoms, an improvement
of conduction function of peripheral nerves and 1a
afferents state as well as a reflex excitability of
functionally different spinal motoneurons. Therapeutic
efficacy of a 10 Hz ICM EMF, particularly for DP primary
stages and diabetes mellitus up to 10-year duration, was
proved.
Neurophysiol Clin. 2001 Aug;31(4):247-52
Interventional neurophysiology for pain
control: duration of pain relief following repetitive
transcranial magnetic stimulation of the motor cortex.
Lefaucheur JP, Drouot X, Nguyen JP.
Service de physiologie-explorations fonctionnelles,
hopital Henri-Mondor, Inserm U421, faculte de medecine,
94010 Creteil, France.
The chronic electrical stimulation of a motor cortical
area corresponding to a painful region of the body, by
means of surgically-implanted epidural electrodes is a
validated therapeutical strategy to control
medication-resistant neurogenic pain. Repetitive
transcranial magnetic stimulation (rTMS) permits to
stimulate non-invasively and precisely the motor cortex.
We applied a 20-min session of rTMS of the motor cortex at
10 Hz using a 'real' or a 'sham' coil in a series of 14
patients with intractable pain due to thalamic stroke or
trigeminal neuropathy. We studied the effects of rTMS on
pain level assessed on a 0-10 visual analogue scale from
day 1 to day 12 following the rTMS session. A significant pain
decrease was observed up to 8 days after the 'real' rTMS
session. This study shows that a transient pain relief
can be induced in patients suffering from chronic
neurogenic pain during about the week that follows a
20-min session of 10 Hz-rTMS applied over the motor
cortex .